John E. Huegel was born in the city of Aguascalientes, Mexico, the son of missionary parents. He also served as a missionary of the Christian Church (Disciples of Christ) in Mexico for forty-two years. During that time, he was the pastor of various Protestant churches, professor and president of the Union Evangelical Seminary in Mexico City, and director of the Center for Theological Studies in the city of San Luis Potosí.
After he retired in 1996, he moved to Texas, where he served briefly as professor of pastoral theology in the Edinburg Theological Seminary and was interim pastor of three congregations. He has written various books in Spanish and English.
He is married to Yvonne West, and they live in New Braunfels, Texas. They have four adult children who all serve the church in different ministries, and eleven grandchildren.