What if angels were directly linked to the existence vampires? Superiors begins in the eighteenth century, when a man named Silas was injured by a fallen angel, and transformed into a vampire. After the attack he began to receive visions he believed came from a higher power. Over the centuries a forceful demon named Mammon, and a powerful vampire named Matthew, became a dangerous threat. Silas is later guided through visions, to help genetically clone giants, so they can potentially take part in a fight with Mammon and Matthew. Later, when the giants have become adults, Silas recruits a man who has the eternal soul of an angel, named Joseph, and a mortal human with an incredible talent, named David, to help him with his mission.